I was having extremely slow response time to input in the google search bar (aka omnibox). I’d close out of Chrome and re-enter, same issue. Every new tab (ctrl + t) I’d start typing a URL or search term and it would take up to 12 seconds for the text to start showing up. And with my misspellings… yeah it was frustrating.

Closed and re-opened Chrome. Same problem.
I disabled all of the extensions. Same problem.
I cleared all of the cache (ctrl shift del). Same problem.
Rebooted the machine. The problem went away for about 2-3 hours and then came right back.
Installed 64bit instead of 32bit. Same problem.
Redid all steps above after upgrading to 64bit. Same problem.

http://www.robschmuecker.com/google-chrome-address-bar-omnibox-getting-slow/

This site had me check for compatibility mode. I wasn’t running in compat mode as this was native supported.

But the delete of cache caught my eye – why does chrome store cached omnibox crud in the default user’s directory?

C:\Users\%Username%\appdata\local\google\chrome\User Data\Default\Cache
Delete everything in there. Restart Chrome.

I had to run taskkill /f /im chrome.exe prior to deleting all of the cache.